Hypothalamic Substance P Release

Hypothalamic substance P release. Attenuated angiotensin responses in mRen2(27) transgenic rats.

Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. ...

Kassinin and substance P stimulate somatostatin release in the rat.

1. The effect of the tachykinin dodecapeptide kassinin, which has been extracted from the skin of several African frogs, on somatostatin release was examined in the rat and compared with that of the neuropeptide substance P. 2. Equimolar doses of the two peptides were injected intravenously and the animal killed at specified intervals after injection. Somatostatin was measured by a specific rad...

Characterisation of Substance P Release following Traumatic Brain Injury

Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.

CHARLES B. NEMEROFF,* PETER W. KALIVAS,'~ ROBERT N. GOLDEN~ a n d ARTHUR J. PRANGE, JR.§ *Duke University Medical Center, Durham, North Carolina 27710, U.S.A., tDepartment of Pharmacology, Louisiana State University Medical Center, New Orleans, Louisiana, U.S.A., ~National Institute of Mental Health, Bethesda, MD 20205, U.S.A. and §University of North Carolina School of Medicine, Chapel Hill, N...

Left vagal stimulation induces dynorphin release and suppresses substance P release from the rat thoracic spinal cord during cardiac ischemia.

Electrostimulatory forms of therapy can reduce angina that arises from activation of cardiac nociceptive afferent fibers during transient ischemia. This study sought to determine the effects of electrical stimulation of left thoracic vagal afferents (C(8)-T(1) level) on the release of putative nociceptive [substance P (SP)] and analgesic [dynorphin (Dyn)] peptides in the dorsal horn at the T(4)...